منابع مشابه
CNS Drug Reviews
Schizophrenia is a devastating mental illness which can seriously compromise the lives of those afflicted, as well as their caretakers and family members. Historically, the cause of this illness has been attributed to demonic possession, sinful behavior, bad parenting, or even the season of the year when the subject was born. Various and sundry interventions have been employed over the years to...
متن کاملCNS Drug Reviews
Bupropion hydrochloride ((±)-2-tert-butylamino)-3 -chloropropiophenone · HCl) is a nonselective inhibitor of the dopamine transporter (DAT) and the norepinephrine transporter (NET) and is also an antagonist at neuronal nicotinic acetylcholine receptors (nAChRs). In animal models used commonly to screen for antidepressant activity, bupropion shows a positive response. Also using animal models, b...
متن کاملCNS Drug Reviews
Mildronate (3-(2,2,2-trimethylhydrazinium)propionate; MET-88; meldonium, quaterine) is an antiischemic drug developed at the Latvian Institute of Organic Synthesis. Mildronate was designed to inhibit carnitine biosynthesis in order to prevent accumulation of cytotoxic intermediate products of fatty acid â-oxidation in ischemic tissues and to block this highly oxygen-consuming process. Mildronat...
متن کاملCNS Drug Reviews
γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain (24,32,40). It has been well documented that the reduction of GABAergic neuronal activity plays an important role in a number of neurological disorders, including epilepsy, anxiety, and pain (17). GABA is synthesized in nerve endings by the transamination of α-ketoglutaraldehyde to glutamic acid, which is...
متن کاملCNS Drug Reviews
Monoamine oxidase (MAO) is an enzyme that metabolizes a wide range of monoamines and is important in the control of the concentration of these neurotransmitters. Several reports have shown that stress can decrease MAO inhibitory activity. An endogenous MAO inhibitory component was first discovered in normal human urine by Glover et al. (22), and the compound responsible for the MAO activity was...
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ژورنال
عنوان ژورنال: CNS Drug Reviews
سال: 2008
ISSN: 1080-563X,1527-3458
DOI: 10.1111/j.1527-3458.2007.00032.x